Sandra M McLachlan Selected Research

Graves Disease (Basedow Disease)

6/2022	Discoveries in Thyroid Autoimmunity in the Past Century.
11/2019	A transgenic mouse that spontaneously develops pathogenic TSH receptor antibodies will facilitate study of antigen-specific immunotherapy for human Graves' disease.
1/2019	Nanoparticles Bearing TSH Receptor Protein and a Tolerogenic Molecule Do Not Induce Immune Tolerance but Exacerbate Thyroid Autoimmunity in hTSHR/NOD.H2h4 Mice.
1/2019	A Mouse Thyrotropin Receptor A-Subunit Transgene Expressed in Thyroiditis-Prone Mice May Provide Insight into Why Graves' Disease Only Occurs in Humans.
12/2016	Critical Differences between Induced and Spontaneous Mouse Models of Graves' Disease with Implications for Antigen-Specific Immunotherapy in Humans.
4/2016	TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective.
1/2016	Withdrawn: TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective.
6/2015	Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease.
5/2015	A unique mouse strain that develops spontaneous, iodine-accelerated, pathogenic antibodies to the human thyrotrophin receptor.
1/2015	Crystal structure of a TSH receptor monoclonal antibody: insight into Graves' disease pathogenesis.

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Sandra M McLachlan Research Topics

Disease

40	Graves Disease (Basedow Disease) 06/2022 - 07/2002
36	Hyperthyroidism 01/2019 - 03/2003
12	Thyroiditis 06/2022 - 10/2003
8	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 04/2003
5	Hypothyroidism 08/2018 - 12/2007
4	Thyroid Diseases (Thyroid Disease) 02/2014 - 08/2002
3	Autoimmune Thyroiditis (Lymphomatous Thyroiditis) 09/2020 - 11/2017
3	Goiter 01/2018 - 03/2003
2	Inflammation (Inflammations) 01/2017 - 11/2005
2	Thyrotoxicosis 05/2015 - 06/2003
2	Infections 02/2014 - 06/2006
2	Hyperplasia 01/2011 - 11/2004
1	Disease Progression 01/2022
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022
1	Cataract (Cataracts) 01/2022
1	Delayed Puberty 08/2021
1	Neoplasms (Cancer) 09/2020
1	Thyroid Neoplasms (Thyroid Cancer) 01/2018
1	Hepatitis C 02/2014
1	Genetic Predisposition to Disease (Genetic Predisposition) 03/2013
1	Bacterial Infections (Bacterial Infection) 01/2012
1	Splenomegaly 06/2010
1	Rickets (Rachitis) 06/2010
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 06/2010
1	Weight Loss (Weight Reduction) 06/2010
1	Colitis 06/2010
1	Autoimmune Polyendocrinopathies (Schmidt Syndrome) 06/2009
1	Vitamin D Deficiency 02/2009
1	Carcinogenesis 10/2007
1	Experimental Autoimmune Myasthenia Gravis (Autoimmune Experimental Myasthenia Gravis) 12/2005
1	Schistosomiasis mansoni 08/2004

Drug/Important Bio-Agent (IBA)

47	Thyrotropin Receptors (Thyrotropin Receptor)IBA 11/2019 - 07/2002
27	AutoantibodiesIBA 01/2022 - 08/2002
23	AntibodiesIBA 11/2019 - 03/2003
15	Thyroid-Stimulating ImmunoglobulinsIBA 04/2016 - 07/2002
9	DNA (Deoxyribonucleic Acid)IBA 09/2012 - 09/2002
8	AutoantigensIBA 02/2014 - 09/2002
7	Thyroglobulin FDA Link 01/2019 - 01/2005
7	Iodide Peroxidase (Deiodinase)IBA 01/2019 - 09/2004
7	Proteins (Proteins, Gene)FDA Link 02/2014 - 05/2003
7	EpitopesIBA 01/2012 - 09/2004
6	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2019 - 07/2002
5	IodidesIBA 09/2020 - 01/2005
5	AntigensIBA 11/2019 - 09/2002
4	IodineIBA 01/2018 - 02/2014
4	CytokinesIBA 11/2014 - 04/2003
3	Protein Subunits (Protein Subunit)IBA 12/2016 - 08/2009
3	Monoclonal AntibodiesIBA 01/2015 - 04/2004
2	LigandsIBA 01/2018 - 03/2013
2	A-factor (Streptomyces)IBA 04/2016 - 01/2016
2	EnzymesIBA 04/2016 - 01/2016
2	Gonadotropin ReceptorsIBA 04/2016 - 01/2016
2	Thyroid HormonesIBA 05/2015 - 10/2007
2	Thyroxine (Levothyroxine)FDA LinkGeneric 07/2014 - 03/2003
2	Long-Acting Thyroid Stimulator (LATS)IBA 04/2012 - 06/2006
2	Vitamin D FDA LinkGeneric 06/2010 - 02/2009
2	Blocking AntibodiesIBA 07/2008 - 10/2005
2	HLA-DR3 Antigen (HLA DR3 Antigen)IBA 12/2006 - 10/2003
2	Immunodominant EpitopesIBA 09/2004 - 08/2002
2	Interleukin-4 (Interleukin 4)IBA 08/2004 - 04/2003
1	Insulin-Like Growth Factor I (IGF-1)IBA 08/2021
1	Growth Hormone (Somatotropin)IBA 08/2021
1	anti-thyroglobulinIBA 09/2020
1	HydrogelsIBA 09/2020
1	Transcription Factors (Transcription Factor)IBA 08/2018
1	Colloids (Colloid)IBA 01/2018
1	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA 10/2014
1	InterferonsIBA 02/2014
1	Leucine (L-Leucine)FDA Link 01/2013
1	Pharmaceutical PreparationsIBA 01/2013
1	Immunoglobulin G (IgG)IBA 01/2013
1	Antithyroid Agents (Antithyroid Drugs)IBA 01/2013
1	Freund's AdjuvantIBA 01/2012
1	LH Receptors (LH Receptor)IBA 07/2011
1	Amino Acids FDA Link 08/2010
1	Dextrans (Dextran)FDA Link 06/2010
1	Calcifediol (Calcidiol)FDA Link 06/2010
1	1,25-dihydroxyvitamin DIBA 06/2010
1	SodiumIBA 06/2010
1	difluprednate FDA Link 03/2009
1	CD40 Ligand (CD40L)IBA 05/2006
1	Abatacept (Orencia)FDA Link 05/2006
1	DisulfidesIBA 01/2006
1	cathepsin SIBA 12/2005
1	Peptides (Polypeptides)IBA 12/2005
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 11/2005
1	Peptide Hydrolases (Proteases)FDA Link 11/2005
1	CardiotoxinsIBA 12/2004
1	Lysosomal Membrane ProteinsIBA 12/2004
1	alpha-galactosylceramideIBA 08/2004
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 08/2004
1	Interferon-gamma (Interferon, gamma)IBA 09/2002

Therapy/Procedure

8	Therapeutics 06/2022 - 10/2005
5	Immunotherapy 06/2022 - 05/2015
1	Injections 09/2020
1	Hemodilution 01/2013
1	Intramuscular Injections 03/2003